Generic Name


Therapeutic Category



Gentamicin Sulphate 0.2% w/w Cream

Topical Antibiotic


     GENTIME  Each tube contains:
    Gentamicin Sulphate IP           0.1% w/w
    White semisolid cream. 10 g of the cream filled in a collapsible aluminum tube.



    Pregnancy:Category C

    Storage: Store between 2- 30°C

    Missed dose:If you forget to apply the cream, apply it as soon as you remember; If your next dose is due within an hour, skip the missed dose; Do not use a double dose to make up for a forgotten dose.


    Pharmacotherapeutic Group: Aminoglycoside Antibiotic

     Pharmacodynamic Properties:

    Gentamicin is a broad spectrum aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth.

    Pharmacokinetic Properties:

    Absorption: Systemic absorption from denuded skin and burns (topical) and from wounds

    Distribution: Diffuse mainly into the extracellular fluids. Crosses the placenta and breast milk.

    Excretion: Via the urine by glomerular filtration virtually unchanged, elimination half life: 2-3 hr


    Skin infections, burns and wounds, bone and soft tissue infections


    Apply to the affected area 3-4 times daily.


    Nausea, abdominal pain, vomiting, diarrhoea, flatulence, elevated liver function values, headache, rashes, exfoliative dermatitis.


    The use of topical antibiotics occasionally allows overgrowth of nonsusceptible organisms, including fungi. If this occurs, or if irritation, sensitization, or superinfection develops, treatment with Gentamicin Sulfate should be discontinued and appropriate therapy instituted.


    Synergistic with ampicillin, benzylpenicillin and other β-lactam antibiotics. Increased risk of severe respiratory depression when used concurrently with anaesthetics or opioids.

    Potentially Fatal: Increased incidence of ototoxicity when combined with ethacrynic acid and furosemide. Cephalosporins, ciclosporin, cisplatin, vancomycin, hydrocortisone and indomethacin potentiate nephrotoxicity. Potentiates neuromuscular blocking agents.


    Contraindicated in individuals with a history of sensitivity to any of its components.



    GENTIME: Each tube contains 10g cream