Cefdinir 125mg Dispersible Tablets
Cefdinir 250mg Dispersible Tablets
|DINIR 125mg|| Each dispersible tablet contains:
|DINIR 250mg||Each dispersible tablet contains:
Cefdinir binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Absorption: Oral Bioavailability- Maximal plasma cefdinir concentrations occur 2 to 4 hours postdose following capsule or suspension administration. Following administration of suspension to healthy adults, cefdinir bioavailability is 120% relative to capsules. Estimated bioavailability of cefdinir capsules is 21% following administration of a 300 mg capsule dose, and 16% following administration of a 600 mg capsule dose. Estimated absolute bioavailability of cefdinir suspension is 25%.
Distribution:The mean volume of distribution (Vdarea) of cefdinir in adult subjects is 0.35 L/kg (±0.29); in pediatric subjects (age 6 months-12 years), cefdinir Vdarea is 0.67 L/kg (±0.38). Cefdinir is 60% to 70% bound to plasma proteins in both adult and pediatric subjects; binding is independent of concentration.
Mean skin blister concentrations were 48% of corresponding plasma concentrations, Mean tonsil tissue concentrations were 24% of corresponding plasma concentrations, Mean sinus tissue concentrations were 16% of corresponding plasma concentrations., Mean epithelial lining fluid concentrations 35% of corresponding plasma concentrations, Mean middle ear fluid concentrations were 15% of corresponding plasma concentrations
Metabolism and Excretion: Cefdinir is not appreciably metabolized. Activity is primarily due to parent drug. Cefdinir is eliminated principally via renal excretion with a mean plasma elimination half-life (t½) of 1.7 (±0.6) hours
Pneumonia, Bronchitis, Otitis Media, Tonsillitis/ Pharyngitis, Sinusitis, Skin & Structure Infection
The recommended dose for Cefdinir in children is 7mg/kg twice daily or 14mg/kg once daily and for adult is 300mg twice daily for 5-10 days.
Diarrhea, rash, vomiting, oral thrush, abdominal pain, vaginitis or vaginal moniliasis or leukopenia
Hypersensitivity to cephalosporin.
Penicillin-sensitive patients; superinfection; seizure; pseudomembranous colitis; pregnancy, lactation; renal or hepatic insufficiency.
Concomitant admin with antacids and Fe reduce the rate and extent of absorption, Probenecid reduces renal elimination and Antacids reduce rate and extent of absorption
DINIR 125mg DT: Each box contains 10 Strips of 10 Tablets
DINIR 250mg DT: Each box contains 10 Strips of 10 Tablets
Pregnancy: Category B
Labor and Delivery
Storage: Store in a cool and dry place; Protect from light, heat and moisture; Keep away from the reach of children.