Pharmacotherapeutic Group:Beta lactam Antibiotic

Pharmacodynamic Properties:CefpodoximeProxetil is third generation oral cephalosporin  with broad activity against gram-positive and gram-negative bacteria showing bactericidal action. It binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall by interfering with transpeptidase enzyme, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Pharmacokinetic Properties:

Absorption: Decreased absorption in conditions of low gastric acidity. Bioavailability: about 50%.Peak plasma time: ≤1 hr

Distribution: Distributed well into tissues, including lungs and tonsils; penetrates into pleural fluid; Protein bound: 18-23%

Metabolism:  De-esterified to cefpodoxime in the intestinal lumen.

Excretion: Half-life: 2-3 hr; prolonged with renal impairment. Urine (80% as unchanged drug) in 24 hr.

INDICATIONS

Acute otitis media, pharyngitis and/or tonsillitis, community-acquired pneumonia, acute bacterial exacerbation of chronic bronchitis, acute and/or uncomplicated urethral and cervical gonorrhea, acute and/or uncomplicated ano-rectal infections in women, uncomplicated skin and skin structure infections,acute maxillary sinusitis, uncomplicated urinary tract infections (cystitis).

DOSAGE & ADMINISTRATION

UTI and RTI:Adult: 100 mg every 12 hours; Child: 8-10 mg/kg/day in 2 divided doses. Max dose: 400 mg daily.

Skin Infection:Adult:400 mg every 12 hours; Child: 8-10 mg/kg/day in 2 divided doses. Max dose: 400 mg daily.

Pharyngitis and/or tonsillitis:Adult:100 mg every 12 hours; Acute community-acquired pneumonia:Adult:200 mg every 12 hours; Uncomplicated gonorrhea (men and women) and rectal gonococcal infections (women): 200 mg single dose

Acute maxillary sinusitis:Adult: 200 mg every 12 hours

Uncomplicated urinary tract infection:Adult: 100 mg every 12 hours

ADVERSE DRUG REACTIONS

Anaphylactic shock; purpuric nephritis, skin rash, pruritus, diarrhoea, nausea, abdominal pain, vomiting.

Potentially Fatal: Pseudomembranous colitis, nephrotoxicity.

PRECAUTIONS

History of allergy to penicillin, severe renal impairment, pregnancy and lactation.

DRUG INTERACTIONS

Antacids or H₂-blockers may decrease the absorption of cefpodoxime. Probenecid inhibits renal excretion.

Potentially Fatal: Monitor renal function during administration. Additive nephrotoxic effects with furosemide.

 CONTRAINDICATIONS

Patients with a known allergy to cefpodoxime or to the cephalosporin group of antibiotics.

PRESENTATION 

CEFIME 200: Each box contains 10 Blister of 10 Tablets per strip