Amoxicillin Trihydrate + Cloxacillin Sodium
Amoxicillin Trihydrate 250mg + Cloxacillin Sodium 250mg Capsules
Each capsule contains:
Amoxycillin Trihydrate BP equivalent to Amoxycillin 250mg
Cloxacillin Sodium BP equivalent to Cloxacillin 250mg
HICLOX is a white to slightly yellowish blend of powder filled in '0' size hard gelatin capsule having grey body and blue cap.
Pharmacotherapeutic Group: β-Lactam penicillin antibiotics
HICLOX has bactericidal action. It inhibits the bacterial cell wall synthesis by interfering with transpeptidase enzyme. Amoxicillin is bactericidal against non β-lactamase producing gm+ve organisms and selected gm-ve pathogens. Cloxacillin is beta lactamase resistant penicillin active against gram positive organisms including beta lactamase producing strains of Staphylococci.
ENT infections, bone and joint infections, respiratory tract infections, skin and soft tissue infections, genitourinary tract infections
Adults: 1-2 capsules three times daily in susceptible infections
Delayed absorption of cloxacillin in the presence of food.
Pregnancy: Category B
Store in a cool and dry place; Protect from light, heat and moisture; Keep away from the reach of children.
Contraindicated in patients with a history of allergic reactions to any penicillins. Attention should be paid to possible cross-sensitivity with other beta lactam antibiotics, e.g. cephalosporins.
Allergy to cephalosporins, infectious mononucleosis, neonates with jaundice, history of convulsions, lactation
Serious AEs: Rarely anaphylactic shock; pseudomembranous colitis. General AEs: GI upsets rash, urticaria, neutropenia, neurotoxicity, agranulocytosis (rarely)
Probenecid decreases the renal tubular secretion of amoxicillin. Concurrent use with HICLOX may result in increased and prolonged blood levels of amoxicillin. Co-administration of probenecid cannot be recommended. In common with other broad-spectrum antibiotics, HICLOX may reduce the efficacy of oral contraceptives.
Each box is supplied with 10 strips of 10 capsules in each.