Amoxicillin Trihydrate 250mg Capsules
Amoxicillin Trihydrate 500mg Capsules
Amoxicillin Trihydrate 100mg/1ml Drops
Amoxicillin Trihydrate 125mg/5ml Dry Syrup
| Each capsule contains:
Amoxycillin Trihydrate BP equivalent to Amoxycillin 250mg
HIMOX 250 is a size '2' hard gelatin capsule having yellow body and green cap filled with white to yellowish blend of granular powder.
|HIMOX 500|| Each capsule contains:
Amoxycillin Trihydrate BP equivalent to Amoxycillin 500mg
HIMOX 500 is a size '0' plain hard gelatin capsule with yellow body and green cap filled with white to yellowish blend of granular powder.
|HIMOX Dry Syrup|| Each 5 ml of the reconstituted suspension contains:
Amoxycillin Trihydrate BP equivalent to Amoxycillin 125mg
|HIMOX Dry Syrup contains white blended granules and powder filled in 78 ml overflow capacity amber colored bottle with outer ring at 60 ml volume for reconstitution.|
Each ml of Reconstituted Suspension Contains:
Amoxycillin Trihydrate BP equivalent to Amoxycillin 100mg
HIMOX Drops contain amber bottle with a label with a mark for 10 ml on the outer side filled with white blend of granular powder labeled as HIMOX PAEDIATRIC DROPS 10 ml.
Pharmacotherapeutic Group: Penicillin antibiotics
Pharmacodynamic properties: HIMOX has bactericidal action. It inhibits the bacterial cell wall synthesis by interfering with transpeptidase enzyme. Amoxicillin is bactericidal against non β-lactamase producing G(+) organisms and selected G(-) pathogens.
Absorption: Rapidly and completely absorbed from the GI tract. Time to peak plasma concentration: 1-2 hr
Distribution: Widely distributes into body tissues and fluids. Crosses the placenta and enters breast milk in small amounts. Plasma protein binding: approximately 20 %
Metabolism: Undergoes partial hepatic metabolism and converted to penicilloic acid.
Excretion: urine (60% as unchanged drug) and faeces. Plasma half-life: 1-1.5 hr
ENT infections, H. pylori infections, dental infections, pneumonia, respiratory tract infections, bronchitis, urinary tract infections, gonorrhea
Adult: 250-500 mg every 8 hr;
Child <10 yrs: 125-250 mg every 8 hr
<40 kg: 20-40 mg/kg daily in divided doses every 8 hours
<3 months: 30mg/kg daily in divided doses every 12 hours
Pregnancy: Category B
Storage: Store capsules at or below 68°F in an air-tight container away from children.
Hypersensitivity to penicillins, cephalosporins, imipenem
Renal and hepatic disease; pregnancy; lactation; infectious mononucleosis
Serious AEs: Neuromuscular hypersensitivity; pseudomembranous colitis General AEs: Hyperactivity, agitation, insomnia, dizziness, maculopapular rash, exfoliative dermatitis, urticaria, hypersensitivity vasculitis, diarrhoea, nausea, vomiting, anaemia, thrombocytopenia, leucopenia, agranulocytosis.
Increased levels with disulfiram and probenicid. Decreased effects with tetracyclines and chloramphenicol.
Serious drug interaction: Increase effects of oral anticoagulants.
HIMOX 250: Each box is supplied with 10 strips of 10 capsules per strip
HIMOX 500: Each box is supplied with 10 strips of 10 capsules per strip
HIMOX DS: Each phial is supplied with 60 ml DS volume to be reconstituted
HIMOX Drops: Each phial is supplied with 10 ml volume to be reconstituted