Ofloxacin 200mg Tablets
Ofloxacin 400mg Tablets
Ofloxacin 50mg/5ml Dry Syrup
|OFROX 200|| Each film coated tablet contains:
Ofloxacin USP 200mg
|OFROX 200 is a yellow oblong film coated tablet with 'T' imprinted on one side.|
Each film coated tablet contains:
Ofloxacin USP 400mg
|OFROX 400 is a yellow oblong film coated tablet with break line on one side.|
Each 5 ml contains:Ofloxacin USP 50mg
|OFROX suspension contains yellow coloured flavoured suspension filled in amber coloured PET bottle.|
Pharmacotherapeutic Group: Fluoroquinolone antibiotics
Ofloxacin is a fluoroquinolone which inhibits bacterial topoisomerase IV and DNA gyrase enzymes required for DNA replication, transcription, repair and recombination. It has activity against a wide range of gram-negative and gram-positive microorganisms.
Absorption:Rapidly and well absorbed from the GI tract (oral), peak plasma concentrations after 0.4-2 hr. Rate, but not extent delayed by the presence of food. Bioavailability: 98%
Distribution: Widely distributed into the body fluids, CSF, tissues, bile (high concentrations), crosses the placenta and enters the breast milk. Protein binding: 20-32%
Excretion: Via urine within 24-48 hr by tubular secretion and glomerular filtration (75-80% as unchanged,
Chronic bronchitis, community acuired pneumonia, SSTI, gonorrhoea, nongonococcal urethritis, cervcitis, typhoid fever, UTI
Adult: 200-400 mg every 12 to 24 hr for 7-14 days
Pregnancy: Category C
Ofloxacin can pass into breast milk and may harm a nursing baby. Do not breast-feed while using ofloxacin.
Storage: Store tablets at room temperature.
Missed dose: Take the missed dose as soon as you remember
Hypersensitivity to ofloxacin or other quinolones, severe hepatic or renal impairment, past history of tendinitis, History of epilepsy or lowered seizure threshold. Children or growing adolescents, history of myasthenia gravis, pregnancy & lactation.
Renal impairment, psychiatric patients or history of psychiatric disease. Avoid excessive exposure to sunlight & UV rays
Severe AEs: Anaphylaxis; rarely seizures
Common AEs: GI disturbances, headache, dizziness, sleep disorders, restlessness, tachycardia, rash, itch, nausea
Probenecid decreases elimination. Antacids may reduce ofloxacin absorption, avoid for 2 hr either side of administration. Cimetidine may increase ofloxacin concentrations. Monitor blood glucose in patients on antidiabetic medication
OFROX 200: Each box is supplied with 10 strips of 10 tabs packed in blisters.
OFROX 400: Each box is supplied with 10 strips of 10 tabs packed in blisters.
OFROX suspension: Each phial is supplied with 60 ml suspension.