Metronidazole 400mg Tablets
Metronidazole 200mg/5ml Suspension
Each film coated tablet contains:Metronidazole BP 400mg
|MET 200 is a yellow, circular biconvex film-coated tablet with 'T' scored on one side|
Each film coated tablet contains:Metronidazole BP 200mg
|MET 400 is ayellow oblong film coated tablet with break line on one side|
|MET Suspension|| Each 5 ml of the suspension contains:
Metronidazole Benzoate IP equivalent to Metronidazole 200mg
|MET suspension contains yellow colored suspension filled in 60 ml amber coloured PET bottle|
Pharmacotherapeutic Group: Antibiotic, antiprotozoal agent
Pharmacodynamic properties: Metronidazole exerts antimicrobial effects in an anaerobic environment. The 5 nitro group undergoes reductive transformation to an active intermediate which then exerts an inhibitory effect against DNA. The reduced metabolite also causes a loss of the helical structure of DNA with subsequent DNA strand breakage.
Absorption:Readily absorbed from the GI tract (oral), absorption delayed by the food. Time to peak plasma concentration:1-2 hr (oral). Bioavailability: 80%
Distribution: Widely distributed in most body tissues and fluids. Crosses the placenta and enters breast milk. Plasma protein binding: <20%
Metabolism: Undergoes hepatic metabolism by side chain oxidation and glucoronide formation.
Excretion: Via urine (as metabolites) and faeces (small amounts). Elimiantion half-life: 8 hr
Anaerobic bacterial infections, amoebiasis, giardiasis, trichomoniasis, vaginosis, amoebiac liver abscesses, H. pylori infections, ulcerative gingivitis, periodontal infections, pelvic inflammatory diseases.
Adults: 1 tablet three times daily for 5 days.
1-3 years: 5ml three times daily for 5 days;
3-7 years: 100-200 mg 4 times daily;
7-10 years: 200-400 mg three times daily;
Doses are given for 5-10 days.
Pregnancy: Category B
Nursing Mothers: Metronidazole can pass into breast milk and may harm a nursing baby. Do not breast-feed while using metronidazole.
Storage: Store tablets at room temperature away from moisture and heat.
Hypersensitivity, blood dyscrasias, active CNS disease, serious neurological disease, seizure, hepatic failure, first trimester pregnancy
Renal and hepatic impairment, avoid alcohol
Seizures, headache, dizziness, peripheral neuropathy, unpleasant metallic taste, furred tongue, GI disturbances, rashes, urticaria, pruritus, raised liver enzymes values, flatulence, nausea
Acute psychosis with disulfiram. Synergistic effect with other antimicrobials
MET 200: Each box contains 20 strips of 10 tabs packed in blisters.
MET 400: Each box contains 20 strips of 10 tabs packed in blisters.
MET Suspension: Each phial is supplied with50 ml suspension.