Generic Name


Therapeutic Category


Tramadol Hydrochloride

Tramadol Hydrochloride 50mg Capsules

Opiod Analgesic




    Each capsule contains:

    Tramadol Hydrochloride BP              50mg

     TRAMA contains size '2' hard gelatin capsule with yellow cap and yellow body.

    Pharmacotherapeutic Group: Opioid analgesics

    Pharmacodynamic properties: Tramadol inhibits reuptake of norepinephrine, serotonin and enhances serotonin release. It alters perception and response to pain by binding to mu-opiate receptors in the CNS.

    Pharmacokinetic properties:

    Absorption: Readily absorbed from the GI tract. Bioavailability: Approximately 70-75% (oral), Onset: Approx1 hour; Duration: 9 hours

    Distribution: Widely distributed. Crosses the placenta and enters breast milk. Protein binding: 20%

    Metabolism: Extensive hepatic first-pass metabolism. Converted to O-desmethyltramadol (active) via N- and O-demethylation by CYP3A4 and CYP2D6 isoenzymes and also via glucorinadation or sulfation.

    Excretion: Via urine (as metabolites). Elimination half-life: Approximately 6 hours


    Post operative pain, Cancer pain, Arthralgia, Neuralgia, Severe acute and chronic pain


     Adults, Moderate to severe pain: 50-100 mg 4-6 hourly. Max: 400 mg/day.



    • May be taken with or without food.

    Food Interaction: 

    • Alcohol may increase nervous system side effects of tramadol.

    Pregnancy:   Category C

    Nursing Mothers

    Tramadol can pass into breast milk and may harm a nursing baby. Do not breastfeed while using tramadol.

    Storage:  Store tablets between 15-30 °C.

    Missed dose: 

    • Take the missed dose as soon as you remember
    • Skip the missed dose if it is almost time for your next scheduled dose
    • Do not take extra medicine to make up the missed dose.

    Hypersensitivity, suicidal patients, acute alcoholism, head injuries, raised intracranial pressure, severe renal impairment, lactation.


    Hypothyroidism, adrenocortical insufficiency, renal or hepatic impairment, history of epilepsy or increased risk of seizures, inflammatory or obstructive bowel disease, myasthaenia gravis, respiratory depression, prostatic hyperplasia. Pregnancy


    Serious AEs: Respiratory depression

    Common AEs: Nausea, dizziness, headache, somnolence, constipation, vomiting, dry mouth, sweating, fatigue, vertigo, euphoria.


    Possible increase in anticoagulation with warfarin. Increased risk of seizures with SSRI, TCA. Increased risk of serotonin syndrome with mirtazapine, venlafaxine, SSRI and MAOI. Reduced analgesic efficacy of tramadol with carbamazepine, 5-HT3 receptor antagonist e.g. ondansetron. Increased respiratory and CNS depression with CNS depressants e.g. alcohol, opioids, anaesthetic agents, narcotics, phenothiazines, tranquilizers or sedative hypnotics.


    Each box is supplied with 10 strips of 10 caps packed in blisters.