Cephalexin 500mg Capsules
Cephalexin 100mg/1ml Drops
Cephalexin 125mg/5ml Dry Syrup
Each capsule contains:
Cefalexin IP equivalent to Anhydrous Cefalexin 500mg
|LEXIN 500 is a size '0' plain hard gelatin capsule with blue cap and grey body filled with white to yellowish blend of granular powder|
|LEXIN Dry Syrup||
Each 5 ml of the reconstituted suspension contains:
Cefalexin IP equivalent to Anhydrous Cefalexin 125mg
|LEXIN DRY SYRUP contains white opaque HDPE bottle with circular mark for 60 ml on the outer side filled with slight white blend of granular powder|
|LEXIN DROPS|| LEXIN DROPS: Each 1 ml of the reconstituted suspension contains:
|LEXIN DROPS contains white blended granules and powder filled in 78 ml overflow capacity amber colored bottle with outer ring at 60 ml volume for reconstitution|
Pharmacotherapeutic Group: First generation cephalosporin antibiotics
Pharmacodynamic properties: Cefalexin binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Absorption: Almost completely absorbed from the GI tract with peak plasma concentrations after 1 hr (oral); may be delayed if taken with food.
Distribution: Widely distributed but does not penetrate the CSF; bile (therapeutic concentrations). Crosses the placenta and enters the breast milk (small amounts). Protein binding: Up to 15%
Excretion: Via the urine within 6 hr by glomerular filtration and renal tubular secretion (>80% as unchanged); via the bile. May be removed by haemodialysis and peritoneal dialysis; elimination half-life: 1 hr
Bone and joint infections, genitourinary tract infections, skin and soft tissue infections, otitis media, respiratory tract infections, uncomplicated cystitis
Adult: 500mg QID;
Child: 25-100mg/kg daily in divided doses.
Pregnancy: Category B
Nursing Mothers: Cefalexin can pass into breast milk and may harm a nursing baby. Do not breast-feed while using cefalexin.
Storage: Store capsules at room temperature (25°C) and in an air-tight container.
Hypersensitivity to cephalosporins
Hypersensitivity to penicillins; pseudomembranous colitis; renal failure; pregnancy and lactation.
Severe AEs: Anaphylactic reactions; nephrotoxicity General AEs: Hypersensitivity, GI disturbances, eosinophilia, neutropenia, leucopenia, thrombocytopenia. abdominal pain, angioedema, dyspepsia
Serious drug interaction: Increased nephrotoxicity with aminoglycosides and furosemide.
Probenecid produces higher and prolonged serum levels.
LEXIN 500: Each box is supplied with 10 strips with 10 capsules in each.
LEXIN DS: Each phial is supplied with 60 ml DS volume to be reconstituted.
LEXIN Drops: Each phial is supplied with 10 ml volume to be reconstituted