Tizanidine Hydrochloride 2mg Tablets
Each uncoated tablet contains:Tizanidine Hydrochloride equivalent to Tizanidine 2 mg
ZANID is a white coloured, round, flat, uncoated tablet with breakline on one side
Pharmacotherapeutic Group: Muscle relaxants, alpha2 adrenergic agonist
Pharmacodynamic properties: Tizanidine a α2 adrenergic agonist is a centrally acting muscle relaxant structurally related to clonidine. It reduces spasticity by increasing presynaptic inhibition of motor neurons and has no direct effect on skeletal muscle, the neuromuscular junction or on monosynaptic spinal reflexes.
Absorption: Absorbed from the GI tract (oral); Peak plasma concentrations: 1-2 hour, Bioavailability: 40%
Distribution: Protein binding: 30% .Elimination half-life: 2-4 hr
Metabolism: Extensive hepatic first pass metabolism mainly via the CYP 450 isoenzyme CYP1A2.
Elimination: Via urine (mainly as inactive metabolites)
Migraine, back pain, spasm, multiple sclerosis, cramps, injury, spasticity
Adult: >18 years: Initially, 2 mg once daily increased according to response by 2 mg increments at intervals of at least 3-4 days up to 24 mg daily in 3-4 divided doses. Max: 36 mg/day
Painful muscle spasm associated with musculoskeletal conditions.
Adult: >18 year: 2-4 mg tid
Pregnancy: Category C
Storage: Store tablet between 15-30 °C.
Hypersensitivity, concomitant ciprofloxacin or fluvoxamine or other potent CYP1A2 inhibitors.
Hepatic or renal insufficiency. Children, elderly, pregnancy and lactation. Monitor LFT regularly. Stop treatment if liver enzymes are raised persistently >3 times upper limit of normal range. Avoid abrupt withdrawal of therapy.
Severe AEs: Hepatitis
Common AEs: Drowsiness, fatigue, dizziness, insomnia, headache, anxiety, nausea, dryness of mouth, GI disturbances, hypotension, bradycardia, muscle pain and weakness, transient increase in serum transaminases, hallucinations.
Potentiates hypotensive effect of antihypertensives. Increased CNS effects with alcohol and CNS depressants. Increased bradycardia with β-blockers and digoxin. Increased serum concentration of tizanidine with CYP1A2 inhibitors.
Each box is supplied with 10 strips of 10 tabs packed in blisters.