Generic Name


Therapeutic Category



Ciprofloxacin 500mg Tablets

Fluoroquinolone Antibiotic


    CIFROX500 Ciprofloxacin Hydrochloride IP equivalentto Ciprofloxacin     500mg White oblong film coated tablet with breakline on one side.



    Food Interaction: Food decreases rate but not extent of absorption. Multi vitamin with minerals interferes with absorption of ciprofloxacin.

    Administration:  May be taken with or without food.

    Pregnancy:Category C

    Storage: Store at 25 °C

    Missed dose: Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.


    Pharmacotherapeutic Group:
    Fluoroquinolones Antibiotics

     Pharmacodynamic Properties:Ciprofloxacin promotes breakage of double-stranded DNA in susceptible organisms and inhibits DNA gyrase, which is essential in reproduction of bacterial DNA.


    Absorption: Rapidly and well absorbed from the GI tract with peak plasma concentration after 2 hour. The absolute bioavailability is approximately 70% with no substantial loss by first pass metabolism.

    Distribution:Bile (high concentrations), CSF (10% of those in plasma in the absence of meningitis); crosses the placenta and enters the breast milk. Protein-binding: 20-40%.

    Metabolism: Converted to oxociprofloxacin, sulfociprofloxacin and other active metabolites

    Excretion: Approximately 40 to 50% of an orally administered dose is excreted in the urine as unchanged drug. The serum elimination half life in subjects with normal renal function is approximately 4 hours.


    Urinary Tract Infections, Cystitis, Respiratory Tract Infections, Gastroenteritis, Skin Infections, Bone and Joint Infections, Enteric Fever


    Adult: 250-750 mg bid depending on the severity and nature of infection. 

    Child: 5-15 mg/kg bid.


    Gastrointestinal disturbances, headache, tremor, confusion, convulsions, rashes, joint pain, phototoxicity, transient increase in serum creatinine; hematological, hepatic and renal disturbances.


    Pregnancy, lactation, epilepsy, history of CNS disorders, severe renal or hepatic dysfunction, myasthenia gravis, may impair ability to drive or operate machinery


    Decreased absorption with concurrent sucralfate, magnesium-aluminum antacids, calcium, iron, zinc and multivitamins. Increased methotrexate and caffeine levels when taken concurrently with ciprofloxacin.  Concurrent use with corticosteroids may increase tendon rupture.


    Hypersensitivity. Not to be used concurrently with tizanidine. Avoid exposure to strong sunlight or sun lamps during treatment.



    CIFROX: Each box contains 10 Blisters of 10 Tablets per strips