Ciprofloxacin E/E Drops
Ciprofloxacin 0.3% w/v Eye/Ear Drops
|CIFROX E/E Drops|| Each 5ml contains:
Ciprofloxacin Hydrochloride IP equivalent to Ciprofloxacin 0.3%w/v
Clear Colourless solution filled in a 10.25 ml overflow capacity gamma sterilized Lupolene vials plugged with gamma sterilized inner seal and capped with gamma sterilized caps.
Storage: Store below 25 °C. Store away from heat, moisture, and light.
Missed dose: Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
Pharmacotherapeutic Group: Fluoroquinolones Antibiotics
Ciprofloxacin promotes breakage of double-stranded DNA in susceptible organisms and inhibits topoisomerase IV and DNA gyrase enzymes, which is essential in reproduction of bacterial DNA.
The maximum reported plasma concentration of ciprofloxacin Eye/Ear Solution was less than 5 ng/mL.
Absorption: Rapidly and well absorbed from the gastrointestinal tract with peak plasma concentration after 2 hour
Distribution:Bile (high concentrations), CSF (10% of those in plasma in the absence of meningitis); crosses the placenta and enters the breast milk. Protein-binding: 20-40%.
Metabolism: Converted to oxociprofloxacin, sulfociprofloxacin and other active metabolites
Excretion: Approximately 40 to 50% of an orally administered dose is excreted in the urine as unchanged drug.
Conjuntivitis, Bacterial Corneal Ulcer, Bacterial Ear Infection, Endopthalmititis, Prophylaxis in the occular surgery
DOSAGE & ADMINISTRATION
For ear infection: Instilled into the affected ear twice or thrice daily (approximately 12 hours apart) for 7 days.
For eye infection:
Corneal Ulcers: The recommended dosage regimen for the treatment of corneal ulcers is two drops into the affected eye every 15 minutes for the first six hours and then two drops into the affected eye every 30 minutes forthe remainder of the first day. On the second day, instill two drops in the affected eye hourly. On the third through the fourteenth day, place two drops in the affected eye every four hours. Treatment may be continued after 14 days if corneal re-epithelialization has not occurred.
Bacterial Conjunctivitis: The recommended dosage regimen for the treatment of bacterial conjunctivitis is one or two drops instilled into the conjunctival sac(s) every two hours while awake for two days and one or two drops every four hours while awake for the next five days.
ADVERSE DRUG REACTIONS
For eyes: Local burning or discomfort, white crystalline precipitation, lid margin crusting, crystals/scales, foreign body sensation, itching, conjunctival hyperemia and a bad taste following instillation, corneal staining, keratopathy/keratitis, allergic reactions, lid edema, tearing, photophobia, corneal infiltrates, nausea and decreased vision.
Should not be used for injection, for inhalation
CIFROX E/E DROPS: Each vial contains 5ml of solution