Doxycycline Hyclate 100mg Capsules
Each capsule contains:
Doxycycline Hyclate IP equivalent to Doxycycline 100mg
|Size '2' hard Gelatin Capsule with GREEN cap and YELLOW body filled with white to yellowish blend of granular powder.|
Food Interaction:Serum levels may be slightly decreased if taken with food, milk, iron or calcium. Decreases absorption of calcium, magnesium, iron, zinc and amino acids.
Administration: Should be taken with food.
Pregnancy: Category D
Doxycycline can pass into breast milk and harm the nursing baby. Donot breast feed while taking doxycycline.
Storage: Store capsules at 15-30 °C
Missed dose: Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Pharmacotherapeutic Group:Tetracycline Antibiotics
Pharmacodynamic Properties:Doxycycline inhibits bacterial protein synthesis by binding to the 30s ribosomal subunit. It has bacteriostatic activity against a broad range of Gram positive and Gram negative bacteria.
Absorption: Readily and almost completely absorbed from the gastrointestinal tract. Food and milk products may decrease absorption. Time to peak plasma concentration: 2 hr.
Distribution: Widely distributed in body tissues and fluids, with excellent penetration into the liver, kidneys and sinuses. Moderate penetration into CSF, crosses the placenta and enters the breast milk. Plasma protein binding: Approx. 80-95%
Metabolism: Partially inactivated in GI tract by chelation formation.
Excretion: Via urine (23%) and faeces (30%). Plasma half-life: 12-24 hr.
Respiratory tract infections, skin infections, acne, bacterial keratitis, trachoma, genitourinary tract infections, syphilis, periodonitis
DOSAGE & ADMINISTRATION
Adults: The usual dose of oral doxycycline is 200 mg on the first day of treatment (administered 100 mg every 12 hours or 50 mg every 6 hours) followed by a maintenance dose of 100 mg/day. The maintenance dose may be administered as a single dose or as 50 mg every 12 hours. In the management of more severe infections (particularly chronic infections of the urinary tract), 100 mg every 12 hours is recommended.
For pediatric patients above eight years of age: The recommended dosage schedule for pediatric patients weighing 100 pounds or less is 2 mg/lb of body weight divided into two doses on the first day of treatment, followed by 1 mg/lb of body weight given as a single daily dose or divided into two doses, on subsequent days. For more severe infections up to 2 mg/lb of body weight may be used. For pediatric patients over 100 pounds the usual adult dose should be used.
ADVERSE DRUG REACTIONS
Permanent staining of teeth, rash, superinfection, nausea, GI upsets, glossitis, dysphagia, photosensitivity, hypersensitivity, haemolytic anaemia, thrombocytopenia, neutropenia and eosinophilia.
Potentially Fatal: Anaphylaxis.
Patient with pre-existing Systemic Lupus Erythematosus (SLE), myasthenia gravis, hepatic and renal impairment, pregnancy.
Patient Counselling: Avoid exposure to direct sunlight or UV light
Prolonged prothrombin time with anticoagulants (e.g. warfarin). May interfere with the bactericidal action of penicillin. Impaired absorption with antacids containing Aluminium, Calcium or Magnesium, oral Zinc, iron salts, and bismuth preparations. Barbiturates, carbamazepine and phenytoin decreases the half life of doxycycline.
Hypersensitivity to doxycycline and any of the tetracyclines. Concurrent use with methoxyflurane. Lactation.
T-DOX: Each box contains 10 Blisters of 10 Tablets per strip