Salbutamol 2mg/5ml Syrup
Each 5 ml contains:
Salbutamol Sulphate equivalent to Salbutamol BP 2mg
|Pink colored, flavoured clear solution, packed in 100 ml amber coloured PET bottle and sealed with ROPP cap.|
Administration: Should be taken on an empty stomach. Take 1 hour before or 2 hours after meals.
Storage: Store between 20-25 °C
Missed dose: Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Pharmacotherapeutic Group: β2 adrenoreceptor agonist.
Pharmacodynamic Properties:Salbutamol is a β2 adrenergic agonist and thus it stimulates β2 adrenergic receptors. Binding of salbutamol to the β2 receptors results in the relaxation of the bronchial smooth muscles. Salbutamol also inhibits the release of bronchoconstricting agentsfrom the mast cells, inhibits the microvascular leakage and enhances the muciliary clearance.
Absorption: Readily absorbed from the GIT; Onset: 30min; Duration: 8 hr.
Metabolism: Hepatic and in the gut wall
Excretion: Via the urine as metabolites and unchanged drug. Some excretion in the faeces.
Asthma, Bronchitis, Emphysema, Cough, COPD
DOSAGE & ADMINISTRATION
5-10 ml three times a day.Adult: 2-4mg (upto 8mg) three times daily; Child: 2mg three times daily
ADVERSE DRUG REACTIONS
Fine skeletal muscle tremor especially hands, tachycardia, palpitation, muscle cramps, headache, paradoxical bronchospasm, angioedema, urticaria, hypotension and collapse.Potentially Fatal: Potentially serious hypokalaemia after large doses.
Pregnancy, mild to moderate pre-eclampsia, arrhythmias, hyperthyroidism, hypertension, diabetes mellitus, myocardial insufficiency, susceptibility to QT-interval prolongation. Monitor serum potassium levels. In women treated for premature labor, monitor hydration status, cardiac and respiratory function minimise volume of infusion fluid. Discontinue treatment if patient develops signs of pulmonary oedema.
Diuretics, corticosteroids and xanthines may augment hypokalaemia. Cardiovascular effects potentiated by Monoamine-oxidase inhibitors, Tricyclic antidepressants, sympathomimetics. Reduces serum levels of digoxin. Hypokalaemia induced by salbutamol increases the risk of digitalis toxicity. Blood Prerssure should be closely monitored if linezolid is used concurrently with salbutamol.
Eclampsia and severe pre-eclampsia, intra-uterine infection, intra-uterine foetal death, antepartum haemorrhage, placenta praevia and cord compression, threatened miscarriage, cardiac disease.
ASMAREX SYRUP: Each bottle contains 100ml of syrup