Cloxacillin 500mg Capsules
Each capsule contains:
Cloxacillin Sodium BP eq. to Cloxacillin 500mg
White to slightly yellowish blend filled in '0' size plain hard gelatin capsule shell having yellow body and green cap.
Food interaction: Delayed absorption in the presence of food; Do not drink juice or carbonated beverage (soda) with TICLOX as it will decrease the effectiveness of the drug; Alcohol may irritate the stomach if taken with TICLOX.
Pregnancy: Category B
Nursing Mother: It is not known whether TICLOX passes into breast milk.
Storage: Store in dry place below 25°C; Keep out of reach of children.
Missed dose: Take the missed dose as soon as you remember; Skip the missed dose if it is almost time for your next scheduled dose; Do not take extra medicine to make up the missed dose.
Pharmacotherapeutic Group: β-lactam antibiotic; Penicillin
Pharmacodynamic properties: TICLOX (Cloxacillin) binds to penicillin-binding protein (PBPs) and inhibits the transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly. This causes formation of a defective cell wall that is osmotically unstable, resulting in bacterial cell death.
Absorption: Incompletely absorbed from the GI tract with peak plasma concentrations after 1-2 hr; Oral bioavailability: 50%
Distribution: Pleural and synovial fluids and bone (therapeutic concentrations), CSF (small amounts except when the meninges are inflamed; crosses the placenta and enters breast milk. Protein-binding: 94%
Metabolism: Minimal metabolism.
Excretion: Via the urine by glomerular filtration and renal tubular secretion (35% of an oral dose); via the bile (Up to 10%). Not removed by dialysis; Elimination half-life: 0.5-1 hr.
250-500mg 4 times daily.
Hypersensitivity to penicillins.
Renal impairment; Pregnancy and lactation; Porphyria; Cephalosporin hypersensitivity.
ADVERSE DRUG REACTIONS
Neutropenia, agranulocytosis; GI upsets; rash. Sore mouth or tongue; Black hairy tongue. Potentially Fatal: Neuromuscular hypersensitivity; pseudomembranous colitis; anaphylaxis.
Coadministration of probenecid or disulfiram may result in higher cloxacillin concentration; Chloramphenicol and tetracycline antagonise bactericidal effect of penicillins; Cloxacillin increases the effect of methotrexate and side effect of allopurinol (may cause rashes); Cloxacillin may decrease the effectiveness of birth control pills.
Potentially Fatal: Increased hypoprothrombinaemic effects of oral anticoagulants.
TICLOX: Each box contains 10 strip packs of 10 capsules per strip.