Generic Name

Composition

Therapeutic Category

Division

Mupirocin

Mupirocin 2% w/w Ointment

Topical Antibiotic

COSMO

    BRAND COMPOSITION DESCRIPTION
    ROCIN

    Mupirocin USP     2%w/w

    5 g of white semisolid ointment filled in a lami tube.
     

    PATIENT INFORMATION

    Administration:

    • ROCIN is for topical use on the skin only.
    • ROCIN is not suitable for ophthalmic use, intranasal use, use in conjunction with cannulae and at the site of central venous cannulation.
    • Avoid using this medication on large areas of damaged or broken skin unless otherwise directed by your doctor.
    • Do not mix the ointment with any other external cream or ointment on the infected area of the skin unless directed by the doctor.
    • Continue to use it for the full amount of time prescribed.
    • Should a possible sensitization reaction or severe local irritation occur with the use of ROCIN, treatment should be discontinued and the product should be washed off.

    Pregnancy: Category B

    Nursing Mother: There is no information on the excretion of ROCIN in milk. If a cracked nipple is to be treated, it should be thoroughly washed prior to breast feeding.

    Storage: Store at room temperature protected from light and heat; Do not refrigerate; Keep out of reach of children.

    Missed dose: If you forget to apply the ointment, apply it as soon as you remember; If your next dose is due within an hour, skip the missed dose; Do not use a double dose to make up for a forgotten dose.

     

    PHARMACOLOGY

    Pharmacotherapeutic Group: Antibiotic

     

    Pharmacodynamic properties: ROCIN (Mupirocin) inhibits isoleucyl transfer-RNA synthetase, thereby arresting bacterial protein synthesis. It is active against gram-positive and some gram-negative bacteria. Mupirocin is rapidly metabolized when it reaches the systemic circulation hence it is used only topically.

     

    Pharmacokinetic properties:

    Absorption: After topical application, mupirocin is only very minimally absorbed systemically through intact skin (<0.3%) and that which is absorbed is rapidly metabolised to the antimicrobially inactive metabolite, monic acid. Penetration of mupirocin into the deeper epidermal and dermal layers of the skin is enhanced in traumatised skin and under occlusive dressings

     

    INDICATIONS

    Secondary infected traumatic skin lesions; Minor burns; Prophylaxis, infection of hair root and boils; Open wounds; Impetigo.

     

    DOSE

    Apply the ointment in the affected area three times daily for 10 days. The treated area may be covered by a dressing.

     

    CONTRAINDICATIONS

    Hypersensitivity

     

    SPECIAL PRECAUTIONS

    Mucosal surface of eye; Pregnancy and lactation; Renal Impairment; Children < 2 months.

     

    ADVERSE DRUG REACTIONS

    Burning, stinging, pain, itching, erythema, dryness, tenderness, dermatitis and rash.

    DRUG INTERACTION

    Do not mix with other preparations as there is a risk of dilution, resulting in a reduction of the antibacterial activity and potential loss of stability of the mupirocin in the ointment unless directed by the doctor.

    PRESENTATION

    Each tube contain 5g of ointment.