Generic Name


Therapeutic Category



Terbinafine 250mg Tablets

Terbinafine 1% w/w Cream




    Terbinafine Hydrochloride BP   1%w/w

    10g of white semisolid cream filled in a collapsible lami tube.


    Terbinafine Hydrochloride BP   250mg

    White, round, biconvex, uncoated tablet with plane surface on both sides.




    • Use the cream on the skin only.
    • Do not apply the medication in the eyes, nose, mouth or inside the vagina.
    • Clean and thoroughly dry the area to be treated.
    • Do not wrap, cover, or bandage the area unless directed to do so by your doctor.
    • Continue to use this medication until the full treatment period is finished, even if symptoms disappear after a few days.

    Pregnancy: Category B

    Nursing Mother: Terbinafine is excreted in breast milk and therefore mothers should not receive NAFIN treatment whilst breast-feeding.

    Storage: Store at room temperature (below 25°C); Protect from light, heat and moisture; Keep out of reach of children.

    Missed dose: Take the missed dose as soon as you remember; Skip the missed dose if it is almost time for your next scheduled dose; Do not take extra medicine to make up the missed dose.


    Pharmacotherapeutic Group: Antifungal agent

     Pharmacodynamic properties: NAFIN (Terbinafine) is an allylamine which has a broad spectrum of antifungal activity. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Terbinafine acts by inhibiting squalene epoxidase, thus blocking the biosynthesis of ergosterol, an essential component of fungal cell membranes. This inhibition also results in an accumulation of squalene.The resultant high concentration of squalene and decreased amount of ergosterol are both thought to contribute to terbinafine's antifungal activity.

     Pharmacokinetic properties:

    Absorption: Absorbed well from the GI tract; Bioavailability (oral): 40%, Minimal absorption (topical); Peak plasma concentrations: 2 hr (oral).

    Distribution: Distributed into stratum corneum of the skin, nail plate, hair (concentrations higher than plasma) and breastmilk; Protein-binding: Extensive.

    Metabolism: Hepatic; converted to inactive metabolites.

    Excretion: Via urine; 17-36 hr (plasma elimination half-life); up to 400 hr (terminal elimination half-life) in prolonged therapy.


    Onychomycosis; Relieving itching, burning, cracking, and scaling associated with jock itch, athlete's foot, ringworm, and other fungal infections of the skin.


    Topical:Apply the cream in the affected area once or twice daily. Duration of therapy: 1-2 wk to treat Tinea corporis and Tinea cruris; 1-wk course is for Tinea pedis; 2-wk course in cutaneous candidiasis and pityriasis versicolor

    Oral: 250mg once daily; Duration of treatment:Infection of groin area, skin and feet: 2-4weeks; Onychomycosis: Fingernail: 6weeks; Toenail: 12weeks


    Hypersensitivity; Severe renal or hepatic impairment; Lactation


    Pre-existing liver or renal impairment; Pregnancy


    Topical: Burning, irritation; itching; blistering/ swelling/ oozing at the application site. Oral: Anorexia, nausea, abdominal pain, taste disturbances, diarrhoea, rash, urticaria. Potentially Fatal: Liver failure, Stevens-Johnson syndrome, neutropaenia.


    Possible increase in levels in drugs metabolised by CYP450 2D6; Decreased terbinafine concentration with rifampicin; Increased terbinafine concentration with cimetidine


    NAFIN 250: Each box contains 10 blister packs of 10 tablets per strip (inner catch cover per 2 strips).

    NAFIN CREAM: Each tube contains 10g of cream.