Generic Name


Therapeutic Category



Glimipiride 1 mg Tablet

Glimipiride 2 mg Tablet

Glimipiride 3 mg Tablet

Glimipiride 4 mg Tablet




    GLIPID 1

    Each uncoated tablet contains:
    Glimepiride      1mg
     Yellow circular uncoated tablets

    GLIPID 2

    Each uncoated tablet contains:
    Glimepiride      2mg
     Green circular uncoated tablets

    GLIPID 3

    Each uncoated tablet contains:
    Glimepiride      3mg
     White,circular, biconvex, uncoated tablets

    GLIPID 4

    Each uncoated tablet contains:
    Glimepiride      4 mg

    Light orange,circular, biconvex, uncoated tablets.


    Pharmacotherapeutic Group: Oral hypoglycemic agent

    Pharmacodynamic properties:  Glimepiride is an orally active hypoglycaemic substance belonging to the sulphonylurea group. Glimepiride binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance. Closing of potassium channel induces depolarisation of the beta cell and results in calcium ion influx through voltage sensitive calcium channels. This increase in intracellular calcium ion leads to insulin release through exocytosis. The extrapancreatic effects are it also increases insulin sensitivity in the peripheral tissue and a decrease insulin uptake by the liver. Glimepiride inhibits the glucose production which in  turn inhibits gluconeogenesis.

    Pharmacokinetic properties: Onset: Peak effect: 2-3 hr; Duration of action: 24 hr; Absorption: Completely absorbed from the GI tract after oral admin; Distribution: Highly protein bound; Metabolism: Hepatic metabolism to 2 main metabolites; Excretion: 60% excreted in urine and 40% in faeces (as metabolites); Elimination half life: about 9 hr.

     INDICATIONS :  Type 2 Diabetes Mellitus, Prevention of diabetic complication

    DOSE :  T2DM: Initially, 1-2 mg once daily. Maintenance: 4 mg daily. Max: 6 mg daily. Renal impairment: Initiate at 1 mg daily; subsequent increments should be based on fasting blood glucose levels.




    • Should be taken with food. Take immediately before or during breakfast, or the 1st main meal of the day. Do not skip meals.
    • May cause disulfiram-like reaction and hypoglycaemia when used with ethanol. Hypoglycaemic risk when used with chromium, garlic, gymnema.

    Pregnancy Category: C

    Storage: Store between 15-30 °C.

    Missed dose: Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. 

    CONTRAINDICATIONS : Hypersensitivity, insulin dependent diabetes, Diabetic ketoacidosis with or without coma, severe renal or hepatic function disorders. 
     SPECIAL PRECAUTIONS :  Increased risk of CV mortality. Elderly; hepatic and renal impairment;  Pregnancy & Lactation.

     ADVERSE DRUG REACTIONS :  Vomiting, GI pain, diarrhoea; pruritus, erythema, urticaria, morbilliform, maculopapular eruptions; leukopenia, agranulocytosis, thrombocytopenia, haemolytic anaemia, aplastic anaemia and pancytopenia; hyponatraemia; changes in accommodation, blurred vision, jaundice.

    DRUG INTERACTIONS :  Hypoglycemic effect potentiated by NSAIDs, salicylates, sulphonamides, chloramphenicol, coumarin, probenecid, fibric acid derivatives, pegvisomant, TCAs, MAOIs and β-adrenergic blocker. Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, oestrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, rifampicin, and isoniazid may reduce hypoglycaemic effect of glimepiride. May increase the serum levels of ciclosporin. Serum levels may be increased by fluconazole.


    GLIPID 1:  Each box contains:
    10 strip pack of 10 tablets per strip.
    GLIPID 2: Each box contains:
    10 strip pack of 10 tablets per strip.
    Glipid 3: Each box contains:
    10 strip  pack of 10 tablets per strip.
    Glipid 4: Each box contains:
    10 strip  pack of 10 tablets per strip.